Laying the Groundwork for Investigating the Link Between Genes and Polycystic Kidney Disease
Date
2018-05Author
Johnson, Anneka L.
Paulich, Katie
Svoboda, Molly
Gingerich, Jamie Lyman
Metadata
Show full item recordAbstract
Our lab studies human polycystic kidney disease using zebrafish and C. elegans as models. Patients with autosomal dominant polycystic kidney disease (ADPKD) suffer from disrupted kidney function due to large, fluid-filled cysts that form in the collecting ducts and kidney tubules. Current treatments for the disease manage cyst growth but do not prevent cyst formation. Although the specific mutations that underlie polycystic kidney disease have been identified, the intervening steps between the altered gene and the disease symptoms remain unclear. We are particularly interested in the link between primary cilia and kidney cysts. This year, we worked to amplify target zebrafish genes, maintain healthy zebrafish and nematode populations, and study the effects in C. elegans of downregulating cilia-related genes through RNA interference (RNAi).
Subject
Polycystic kidney disease (PKD)
Zebrafish
Spinner mutant
Posters
Permanent Link
http://digital.library.wisc.edu/1793/79161Description
Color poster with text, images, charts, photographs and graphs.