Polyamide-chlorambucil conjugates
File(s)
Date
2008Author
Mohandas, Appesh
Advisor(s)
Warren, Christopher
Ansari, Aseem
Metadata
Show full item recordAbstract
Polyamides are chemically engineered molecules made up of sequences of pyrolle and imidazole rings. In particular sequences, these molecules have been shown to have a very high affinity and specificity for nucleic acids, and can therefore be arranged to bind a specific sequence of DNA. By combining such a compound with a known anti-cancer agent, Chlorambucil, and using microarray technology to query the specificity and affinity with which this conjugate binds DNA, and in particular which sequences are bound
Subject
Biochemistry
Permanent Link
http://digital.library.wisc.edu/1793/37478Description
27 p.